The influence of serum Hcy and EGF levels on cognitive dysfunction in patients with schizophrenia
Objective To explore the relationship between cognitive dysfunction and serum levels of homocyste-ine(Hcy)and epidermal growth factor(EGF)in patients with schizophrenia.Methods A retrospective analysis was conducted on the clinical data of 110 patients with schizophrenia admitted to our hospital from January 2020 to January 2023.After admission,their cognitive function was evaluated using the Montreal Cognitive Assessment Form(MoCA).According to the scoring results,they were divided into a group without cognitive impairment and a group with cogni-tive impairment.Compare two sets of general data[gender,age,body mass index(BMI),marital status,smoking history,alcohol consumption history,use of high levels of anticholinergic drugs,and differences in serum Hcy and EGF levels].Use ROC to determine the value of serum Hcy and EGF in predicting cognitive dysfunction in patients with schizophrenia.Use multivariate logistic regression analysis to identify risk factors for cognitive dysfunction in patients with schizophrenia.Results After admission,the patients were evaluated for their cognitive function using the MoCA score.According to the score results,the incidence of no cognitive impairment was 63.64％(70/110)in 110 patients,and the incidence of cognitive impairment was 36.36％(40/110).They were divided into the no cognitive impairment group and the cognitive impairment group,respectively.There was no statistically significant difference in gender,age,BMI,marital status,smoking history,and drinking history between the two groups(P＞0.05).The proportion of high content anticholinergic drugs used,as well as serum Hcy and EGF,were significantly lower in the non cogni-tive impairment group than in the cognitive impairment group,with a statistically significant difference(P＜0.05).After ROC analysis,it was confirmed that serum Hcy and EGF can both be used for predicting cognitive impairment in first-episode schizophrenia patients,with areas under the curve of 0.974 and 0.788,respectively,with P＜0.05.Multivariate logistic regression analysis confirmed that the use of high levels of anticholinergic drugs,Hcy ≥ 14.575 μmol/L,and EGF≥1698.275pg/mL were risk factors for cognitive impairment in patients with schizophrenia,all with P＜0.05.Conclusion Cognitive function in patients with schizophrenia is influenced by many factors.When Hcy ≥14.575 μmol/L and EGF≥1698.275pg/mL,it can be used to predict cognitive dysfunction.
SchizophreniaHomocysteineEpidermal growth factorCognitive function
NETL
NSTL
万方数据
