Effects of olanzapine on cognitive function and serum inflammatory factor levels in patients with schizophrenia
Objective To investigate the effects of olanzapine treatment for schizophrenia patients on cognitive function and serum inflammatory factor levels.Methods A total of 84 patients with schizophrenia from January 2020 to February 2023 in the Fifth People's Hospital of Linfen City were included.They were divided into two groups accord-ing to the randomization method of lottery,41 cases in the risperidone group and 43 cases in the observation group.The risperidone group was treated with risperidone and the olanzapine group was treated with olanzapine,both for 12 weeks.The negative and positive syndrome scale(PANSS),Montreal cognitive assessment scale(MoCA)and serum inflammatory factor levels were compared before and after treatment.Results After treatment,all PANSS scores were significantly lower in both groups than before treatment,and the olanzapine group was significantly lower than the ris-peridone group after treatment(P＜0.05).The MoCA score was significantly higher and the serum interleakin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels were significantly lower in both groups after treatment,and the MoCA score was higher in the olanzapine group and the serum inflammatory factor level was significantly lower than that in the risperidone group after treatment(P＜0.05).Conclusion Olanzapine treatment for schizophrenia was able to achieve significant clinical efficacy and promote improved cognitive function,possibly associated with downregulation of serum inflammatory factor levels.
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