Study on inflammatory response,thyroid function,sex hormones and cortisol in male patients with de-pressive disorder in different age
Objective To investigate the changes of inflammatory response,thyroid function,sex hormones and cortisol in male patients with depressive disorder at different ages and their correlations,and to explore more personal-ized treatment plans.Methods A total of 166 male patients with moderate to severe depressive disorder,hospitalized in Kailuan Mental Health Center from January 2022 to October 2022 were selected.They were divided into the young,the middle-aged and the elderly groups.The general data,inflammatory response,thyroid function,sex hormones and corti-sol levels of the patients were collected.Results The age of patients was negatively correlated with White blood cell(WBC)count,Lymphocyte count,Free triiodothyronine(FT3)level and Thyroid stimulating hormone(TSH)level,and posi-tively correlated with Cortisol level.The canonical correlation results showed that the correlation between sex hormone re-lated indexes and cortisol related indexes was the most significant,and the canonical correlation coefficient square was 0.40.Conclusion With the increase of age,WBC count,lymphocyte count,FT3 and TSH levels in male patients with mod-erate and severe depressive disorder show a downward trend,and hypothalamic-pituitary-epinephrine axis is more likely to have dysfunction.The hypothalamic-pituitary-gonadal/epinephrine axis may play a positive coordination role.
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