The Effect of agomelatine in the treatment of depression patients with sleep disorder
Objective To explore the clinical efficacy of agomelatine in the treatment of depression with sleep disorder.Methods Ninety-six patients with depression and sleep disorders from March 2020 to January 2023 were selected as the study subjects.They were divide into two groups using the simple random method.The control group was treated with sertraline,and the observation group was treated with agomelatine on the basis of the control group for 2 months.The improvement of negative emotions through Hamilton Anxiety Scale(HAMA)and Depression Scale(HAMD)before and after treatment were evaluated.The sleep improvement situation were evaluated using heart lung coupled sleep quality assessment system.Results After treatment,the HAMA score and HAMD score of both groups of patients significantly decreased,and the observation group had lower scores than the control group(P＜0.05).Af-ter treatment,the total sleep,deep sleep,and rapid eye movement(REM)sleep time of the two groups significantly increased,while light sleep and awakening time significantly decreased.Moreover,the observation group had better cardiopulmonary coupling parameters than the control group(P＜0.05).Conclusion Agomelatine can effectively im-prove negative emotions and sleep quality in the treatment of depression with sleep disorders.
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