Correlation analysis of serum Hcy and CysC levels with depression and cognitive function in epilepsy patients
Objective To explore the correlation analysis between serum homocysteine(Hey),cystatin C(CysC),depression,and cognitive function in epilepsy patients.Methods 55 epileptic patients admitted to our hospital from January 2022 to January 2023 were selected as the study group,and 53 healthy individuals who under-went physical examinations at our hospital during the same period were selected as the control group.Depression status was evaluated using the Hamilton Depression Scale(HAMD),and cognitive function was evaluated using the Montreal Cognitive Assessment(MoCA).Observe the levels of serum Hcy and CysC,depression,and cognitive function in two groups,and use Spearman correlation analysis to analyze the correlation between depression and serum Hcy and CysC levels,as well as the correlation between cognitive function and serum Hcy and CysC levels.Results The levels of serum Hcy and CysC in the study group were higher than those in the control group(P＜0.05).The HAMD score of the study group was higher than that of the control group,while the MoCA score was lower than that of the control group(P＜0.05).Spearman correlation analysis showed that HAMD score was positively correlated with serum Hcy and CysC levels(r=0.635,0.587,P＜0.001).The MoCA score was negatively correlated with serum Hcy and CysC levels(r=-0.556,-0.514,P＜0.001).Conclusion Epilepsy patients have higher serum Hcy and CysC levels than normal individuals,and their depressive mood and cognitive impairment are more severe.Depression is positively correlated with serum Hcy and CysC levels,while cognitive function is negatively correlated with serum Hcy and CysC levels.
Serum homocysteineSerum cystatin CEpilepsyDepressionCognitive function
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