Effect of Diazoxide on Cognitive Function and Negative Emotions After Hip Arthroplasty in the Elderly
Objective To investigate the effect of diazoxide on cognitive function and negative emotions after hip arthroplasty in the elderly.Methods A total of 92 hip arthroplasty patients from February 2020 to March 2023 in our hospital were divided into control group and observation group by coin flip randomization method,45 cases and 47 cases,respectively.In the control group,intraoperative anesthesia was maintained with remifentanil and propofol,and in the observation group,diazoxide was used in combination with the control group.The Montreal Cognitive Assess-ment(MoCA),Hospital Anxiety and Depression Scale(HAD)were compared between the two groups before and 6h,24h,3d and 7d after surgery.Results The6h,24h,and 3d postoperative MoCA scores were significantly lower than those before surgery in both groups(P＜0.05).The difference between 7d postoperatively and preoperatively was not significant(P＞0.05).The 6h,24h,and 3d postoperative MoCA scores were significantly higher in the observation group than in the control group(P＜0.05).The HAD scale anxiety and depression scores were significantly higher in both groups at 6h,24h,3d,and 7d postoperatively than before surgery,and were significantly lower in the observa-tion group than in the control group(P＜0.05).Conclusion Dizocine used as an adjunct to anesthesia in geriatric hip arthroplasty can reduce postoperative cognitive impairment and reduce negative emotions such as postoperative anxiety and depression.
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