Relationship between symptoms and serum IL-6 and IL-1 levels in patients with depression after ischemic stroke
Objective To investigate the relationship between symptoms and serum interleukin-6(IL-6)and interleukin-1(IL-1)expression in patients with post-stroke depression(PSD).Methods A total of 120 patients with ischemic stroke admitted to our hospital from January 2021 to January 2023 were selected and studied,and divided into PSD group(n=50)and NPSD group(n=70)according to Hamilton depression-17(HAMD-17)scale.Basic data were compared between the two groups,and pearson correlation was used to analyze the relationship between serum IL-6 and IL-1 levels and HAMD-17 scale,and the levels of IL-6 and IL-1 in predicting ischemic PSD was analyzed by ROC and multivariate Logistic regression..Results IL-6 and IL-1 levels in PSD group were significantly higher than those in NPSD group(P＜0.05).Correlation analysis showed that the levels of serum IL-6 and IL-1 was positively correlated with the score of HAMD-17 scale(P＜0.05).Multivariate Logistic regression analysis confirmed that the high levels of IL-6 and IL-1 was a risk factor for ischemic PSD(P＜0.05).ROC analysis confirmed that serum IL-6 and IL-1 levels could be used to predict ischemic PSD,and the area under the curve was 0.677 and 0.849,respec-tively,with P＜0.05.Conclusion The high levels of serum IL-6 and IL-1 is a risk factor for ischemic PSD,and is positively correlated with the severity of depressive symptoms,which may have a certain diagnostic value for ischemic PSD.
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