Analysis of the association between dialysis adequacy and anxiety and depression in maintenance hemo-dialysis patients based on urea dynamics model
Objective Exploring the correlation analysis between dialysis adequacy and anxiety and depres-sion in maintenance hemodialysis(MHD)patients based on the urea kinetic model(UKM).Method A retrospec-tive analysis was conducted on the clinical data of64 MHD patients admitted from June 2021 to June 2022.Based on the clinical data,the patients were divided into dialysis charging group(44 cases)and dialysis non charging group(20 cases),Compare two sets of UKM parameters[Time average concentration of urea(TACruea),urea clearance index(KT/V),and protein catabolism rate(PCR)].The ROC curve was used to obtain the boundary values of UKM param-eters,and the levels of anxiety self rating scale(SAS)and depression self rating scale(SDS)were compared among pa-tients with different levels of UKM parameters.Spearman correlation analysis was used to analyze the correlation between UKM parameters and SAS and SDS scores.Result The TACruea and PCR values in the dialysis sufficient group were significantly higher than those in the dialysis non sufficient group(t=20.406,5.390,P＜0.05).There was no differ-ence in KT/V values between the two groups(P＞0.05).Through ROC curve analysis,it can be seen that the TACurea cutoff value is 16.23 mmol/L,and the PCR cutoff value is 0.61 g/kg-1·d-1.The SAS and SDS scores of patients with TA-Cruea ≥ 16.23 mmol/L were significantly lower than those of patients with TACruea＜16.23 mmol/L(t=3.222,5.209,P＜0.05).The SAS and SDS scores of patients in the PCR ≥ 0.61 g/kg-1·d-1 group were significantly lower than those in the PCR＜0.61 g/kg-1·d-1 group(t=5.043,3.443,P＜0.05).Spearman correlation analysis showed a significant nega-tive correlation between TACurea,PCR,SAS,and SDS scores(r=-0.367,-0.563,-0.560,-0.410,P＜0.01).Conclusion Based on the UKM model,the dialysis adequacy of MHD patients can be accurately evaluated,and there is a significant correlation between dialysis adequacy and patient anxiety and depression.The more thorough dialy-sis,the lower the level of anxiety and depression in patients.
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