Analysis of risk factors associated with anxiety or depression in patients with gastroesophageal reflux disease
Objective To investigate the risk factors associated with anxiety and depression in patients with gastro-esophageal reflux disease(Gastroesophageal reflux disease,GERD).Methods A retrospective study was conducted on the basic formation of clinical data of 177 outpatients with GERD in a tertiary hospital.Based on the scores obtained from the Hospital Anxiety and Depression Scale,the patients were divided into two groups:patients with symptoms of anxiety or depression group,and patients without symptoms of anxiety or depression group.Univariate and multivariate Logistic regression analysis were performed to identify the risk factors contributing to comorbid anxiety or depressed mood in pa-tients with GERD.Results Among the 177 patients with GERD,49.7％of the patients had comorbid anxiety or depres-sion.The presence of constipation(OR=2.289,95％CI 1.138-4.605,P＜0.05),laryngopharyngeal reflux(OR=2.226,95％CI 1.112-4.459,P＜0.05),poor sleep quality(OR=3.786,95％CI 1.900-7.544,P＜0.05),and experiencing stressful events within a six-month period(OR=4.569,95％CI 1.643-12.706,P＜0.05)were independent risk factors for anxiety or depression in patients with GERD.Conclusion The incidence of anxiety or depression is high in patients with GERD.Constipation,laryngopharyngeal reflux,poor sleep quality,and stressful events within a six-month period are independent risk factors for anxiety or depression in patients with GERD.Targeted interventions should be provided in clinical practice to reduce the incidence of anxiety or depression in GERD patients.
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