Study on sleep status and its relationship with anxiety and depression in patients with Parkinson's disease
Objective Sleep survey analysis of Parkinson's disease(PD)patients and its relationship with anxiety and depression.Method Retrospective analysis from January 2020 to December 2022 in our hospital for treatment of the clinical data of 130 patients with Parkinson's disease,according to the Pittsburgh sleep quality index(PSQI)score all pa-tients were divided into sleep disorder(SD)group(n=88),SD(n=42).Baseline data and scores of the two groups were compared[Simple Intelligent Mental State Examination Scale(MMSE),Montreal Cognitive Assessment Scale(MoCA),Unified Parkinson's Disease Rating Scale Ⅲ(UPDRS-Ⅲ),Hamilton Anxiety Scale(HAMA),and Hamilton Depression Scale(HAMD)].Multivariate Logistic regression was used to analyze the influencing factors of SD in PD patients.Spear-man correlation coefficient was used to analyze the correlation between PSQI score and PDQ-8,UPDRS-Ⅲ,HAMA and HAMD scores in PD patients.Result The proportion of equivalent dose of dopamine hydrazine tablets ≥ 600 mg,PDQ-8,UPDRS Ⅲ,HAMA,and HAMD scores in the SD group were higher than those in the non SD group(P＜0.05).Multiple logistic regression analysis confirmed that the equivalent dose of dopamine hydrazine tablets,PDQ-8,UPDRS-Ⅲ,HAMA,and HAMD were all risk factors for SD in Parkinson's patients,with P＜0.05.Correlation analysis showed that the PSQI score of first-onset Parkinson's disease patients was positively correlated with PDQ-8,UPDRS Ⅲ,HAMA,and HAMD(P＜0.05).Conclusion The incidence of SD is higher in Parkinson's patients,and depression,anxiety,quality of life,and movement disorders are related to the severity of SD in Parkinson's patients.
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