Clinical effect of estradiol tablets/estradiol dexmedroxyprogesterone tablets combined with psychological intervention treatment on perimenopausal women with anxiety and depression
Objective To evaluate the clinical effect of estradiol tablets/estradiol medroxyprogesterone tablets combined with psychological intervention treatment on perimenopausal anxiety/depression patients.Methods 120 study subjects who met the standards in our menopausal clinic from February 2021 to February 2023 were included.They were randomly divided into a control group(psychological intervention group)of 59 cases and an observation group(estradiol/estradiol dexamethasone combined psychological intervention group)of 61 cases,and were followed up for 3 months.The Hamilton Anxiety Rating Scale(HAMA)and Hamilton Depression Rating Scale(HAMD)were used to evaluate anxi-ety/depression status,the Pittsburgh Sleep Quality Index(PSQI)was used to evaluate sleep quality,and the Modified Kupperman Index(KMI)was used to evaluate menopausal symptoms.Measure the changes in levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),5-hydroxytryptamine(5-HT),and norepinephrine(NE)in two groups of study subjects.Compare the differences in the above indicators between the two groups at baseline and at 3 months of treatment.Results At baseline,there was no statistically significant difference in FSH,LH,E2,5-HT,NE levels,HAMA,HAMD,PSQI,and KMI scores between the two groups(P>0.05).After 3 months of treatment:The levels of FSH,LH,and E2 in the control group showed no significant changes compared to baseline(P>0.05),while the levels of FSH,LH in the observation group decreased significantly,while E2 levels increased significantly(P<0.05).The levels of 5-HT and NE in both groups increased,and the observation group was significantly higher than the control group(P<0.05).The scores of HAMA,HAMD,PSQI,and KMI in both groups decreased,and the ob-servation group was significantly lower than the control group(P<0.05).Conclusion For perimenopausal women with anxiety/depression,psychological intervention combined with hormone replacement therapy can significantly improve the endogenous hormone levels of perimenopausal women,more effectively alleviate anxiety and depression levels,and im-prove sleep quality.It is the preferred treatment plan for non contraindicated perimenopausal women.