Effects of quetiapine fumarate tablets on serum neurocytokines and neuroelectrophysiological parameters in patients with first-episode schizophrenia
Objective To investigate the effects of quetiapine fumarate tablets on serum neurocytokines and neuroelectrophysiological parameters in first-episode schizophrenics.Methods A total of 96 patients with first-onset schizophrenia from January 2021 to February 2022 in our hospital were enrolled and divided into control group(aripip-razole treatment)and observation group(quetiapine fumarate treatment)according to the method of random number table,with 48 cases each;Compare the clinical treatment effect,serum neurocytokines and neuroelectrophysiological parameters between the two groups.Results After treatment,the level of glial fibrillary acidic protein factor(GFAP)in both groups was lower than that before treatment(P＜0.05),and the level in the observation group was lower than that in the control group(P＜0.05).The total effective rate and the levels of brain-derived neurotrophic factor(BDNF)and nerve growth factor(NGF)in the observation group were higher than those in the control group(P＜0.05).After treatment,the latency of P300 and N2-P3 in both groups was shortened(P＜0.05),the amplitude of P300 and N2-P3 increased in both groups(P＜0.05).The improvement range of the observation group was greater than that of the control group(P＜0.05).Conclusion Quetiapine fumarate tablet is superior to aripiprazole alone in the first-episode schizo-phrenia,which canimprove serum neurocytokines and neuroelectrophysiological parameters.
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