阿立哌唑和利培酮治疗精神分裂症患者的效果和不良反应分析
Analysis of the efficacy and adverse reactions of aripiprazole and risperidone in the treatment of schizophrenia
程丹 1周宇 1吴传东1
作者信息
- 1. 海南省安宁医院药剂科(海口,570100)
- 折叠
摘要
目的 探讨精神分裂症患者应用阿立哌唑与利培酮治疗的临床效果和不良反应.方法 于2021年10月～2022年10月采集病例资料入档,对象为医院收治的精神分裂症患者共计纳入100例,纳入对象基于"随机数字表法"规范化分组处理,划分为对照组(予以利培酮治疗)与观察组(予以阿立哌唑治疗),各纳入50例;观察对比两组临床疗效、不良反应发生率、阳性与阴性症状量表(PANSS)评分、糖脂代谢指标、血清催乳素水平.结果 两组治疗总有效率组间对比无显著差异(P＞0.05);较治疗前,两组治疗后PANSS评分均下降(P＜0.05),治疗前、后两组PANSS评分组间比较无显著差异(P＞0.05);对照组治疗后TC、TG、FPG水平均高于治疗前、同期观察组(P＜0.05),观察组治疗前后总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FPG)水平组内比较无显著差异(P＞0.05);对照组治疗4周、8周、12周血清催乳素水平均升高,且均高于观察组(P＜0.05),观察组治疗前后血清催乳素水平组内比较无显著差异(P＞0.05);两组不良反应发生率比较(P＞0.05).结论 精神分裂症患者应用利培酮与阿立哌唑治疗,治疗效果相当,且治疗安全性有保障,但阿立哌唑对糖脂代谢和催乳素水平影响相对小.
Abstract
Objective To explore the clinical effects of aripiprazole and risperidone in the treatment of schizo-phrenia.Methods Case data were collected and filed from October 2021 to October 2022.A total of 100 patients with schizophrenia admitted to the hospital were included.The participants were divided into a control group(treated with risperidone)and an observation group(treated with aripiprazole)based on a standardized random number table method,with 50 patients included in each group.Observe and compare the clinical efficacy,incidence of adverse re-actions,positive and negative symptom scale(PANSS)scores,glucose and lipid metabolism indicators,and serum prolactin levels between two groups.Results There was no significant difference in the total effective rate between the two groups(P＞0.05).Compared with before treatment,the PANSS scores of both groups decreased after treatment(P＜0.05),and there was no significant difference between the two groups in terms of PANSS scores before and after treatment(P＞0.05).The levels of TC,TG,and FPG in the control group after treatment were higher than those in the observation group before and during the same period of treatment(P＞0.05).The serum prolactin levels in the control group increased at 4,8,and 12 weeks of treatment,and were higher than those in the observation group(P＜0.05).Comparison of the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The risperidone and aripiprazole to treat schizophrenia has a comparable therapeutic effect and guaranteed safety,but aripiprazole has a relatively small impact on glycolipid metabolism and prolactin levels.
关键词
阿立哌唑/利培酮/精神分裂症/不良反应Key words
Aripiprazole/Risperidone/Schizophrenia/Adverse reactions引用本文复制引用
出版年
2024
NETL
NSTL
万方数据