Analysis of drug use and adverse reactions in 743 hospitalized patients with schizophrenia
Objective To analyze the medication situation and adverse reactions of 743 hospitalized patients with schizophrenia,and guide clinical medication.Methods We selected hospitalized patients with a clear diagnosis of schizophrenia in our hospital as samples,analyzed the daily medication use of 743 patients,and recorded antipsychot-ic and adjuvant drugs(beta blockers,benzodiazepines,non benzodiazepine sedative and hypnotic drugs,antidepres-sants,anxiolytics,antiepileptics,mood stabilizers),etc.Results The overall use of antipsychotic drugs showed 311 cases of clozapine(31.01％),216 cases of risperidone(21.54％),136 cases of olanzapine(13.56％),121 cases of quetiapine(12.06％),and 93 cases of aripiprazole(9.27％).484 cases(65.14％)were treated with antipsychotic drugs alone,258 cases(34.72％)were treated with two antipsychotic drugs in combination,and 1 case(0.13％)was treated with three antipsychotic drugs in combination.In auxiliary medication,342 cases of beta blockers,accounting for 46.03％.21 cases of benzodiazepines and 5 cases of non benzodiazepine sedative and hypnotic drugs,accounting for 2.82％and 0.67％respectively.There were 62 cases of antidepressants,6 cases of anxiolytics,307 cases of mood stabilizers,and 13 cases of antiepileptic drugs,accounting for 8.34％,0.81％,41.32％,and 1.75％,respec-tively.The top five incidence rates of adverse drug reactions were 328 cases(44.20％)of extrapyramidal system reac-tion,284 cases(38.27％)of hyperlipemia,88 cases(11.86％)of liver dysfunction(elevated transaminases),39 cases(5.26％)of leukopenia,and 35 cases(4.71％)of hyperuricemia.Conclusion The antipsychotic treatment for hospitalized patients with schizophrenia is mainly based on a single medication regimen,and most of them use second-generation(atypical)antipsychotic drugs,with a basically reasonable medication regimen;In adjuvant therapy,beta blockers and mood stabilizers is relatively high.The incidence of adverse drug reactions is relatively high.
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