Correlation Analysis of the Midbrain Echogenicity and Cerebrovascular Reactivity in Patients with Depression
Objective To investigate the correlation between midbrain raphe(MBR)echo and cerebral vascu-lar reactivity(CVR)in patients with depression.Methods Sixty patients diagnosed with depression who visited the psychiatry outpatient clinic of our hospital from January 2023 to September 2023 were selected as the study group,and 70 healthy individuals undergoing physical examination in the same period were selected as the control group.Record and compare the age,gender,educational levels,Breath-Holding Index(BHI),and positivity rates of MBR echo abnormalities between two patient groups.Subsequently,analyze the correlation between Hamilton Depression Rating Scale(HAMD)scores and both BHI and MBR echo abnormalities.The correlation between Hamilton Depression Rating Scale(HAMD)scores and BHI and abnormal MBR echo was then analyzed.Results There was no significant differ-ence in the basic clinical data between the two groups(P＞0.05).The BHI of the study group(0.58±0.09 vs.0.84±0.10,t=-14.862,P=0.000)was significantly higher than that of the control group(P＜0.05).The positive rate of decreased MBR echo in the study group(87.5％vs.28.6％,x2=27.857,P=0.000)was significantly higher than that in the control group(P＜0.05),with no statistically significant difference in other indices(P＞0.05).The decrease in MBR echo in the study group was negatively correlated with the increase in HAMD scores(r=-0.325,P=0.011),while there was no linear correlation between BHI and HAMD scores(r=-0.221,P＞0.05).Conclusion A decrease in MBR(midbrain echo)is negatively correlated with HAMD(Hamilton Depression Rating Scale)scores.For patients unable to fully cooperate with the HAMD scale assessment,using transcranial ultrasound to detect MBR echo can serve as an auxiliary method for diagnosing depression.
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