Expression and clinical significance of serum inflammatory factors in patients with depression and insomnia
Objective To observe the expression level of serum inflammatory factors in patients with depres-sion and insomnia and explore its clinical significance.Methods A total of 112 patients with depression and insomnia admitted to our hospital from March 2021 to March 2023 were selected as the observation group,and 50 healthy sub-jects were selected as the control group.17-Item Hamilton Depression Scale(HAMD-17)score and Pittsburgh Sleep Quality Index(PSQI)score were recorded.The levels of serum inflammatory factors such as interleukin-6(IL-6),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)were detected in all groups.Pearson correlation coef-ficient was used to test the correlation.Results HAMD-17 scores and PSQI scores in the observation group were(22.16±5.82)scores and(15.09±2.35)scores,respectively,higher than those in the control group(6.09±0.74)scores and(7.13±2.78)scores,P＜0.05.Serum levels of IL-6,IL-1β and TNF-α in the observation group were(28.95±6.32)pg/mL,(35.82±8.37)pg/mL and(45.69±5.81)pg/mL,respectively.It was higher than that of control group(24.17±3.55)pg/mL,(30.29±3.75)pg/mL,(42.37±3.12)pg/mL,P＜0.05.There were significant differences in HAMD-17 scores,PSQI scores and serum levels of IL-6,IL-1β and TNF-α in mild,moderate and severe groups(P＜0.05).HAMD-17 score was positively correlated with PSQI score and serum levels of IL-6,IL-1β and TNF-αin patients with depression and insomnia(P＜0.05).Conclusion Compared with the healthy control group,the se-rum levels of IL-6,IL-1β and TNF-α were higher in patients with depression and insomnia,and the serum levels of inflammatory factors were correlated with the severity of depression.
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