The impact of maternal childhood trauma affecting trauma,anxiety and amygdala brain network in adolescent depressed patient
Objective Understanding the impact of maternal childhood trauma on childhood trauma and anxiety in adolescents with depression and on the brain mechanisms of their offspring.Methods Scales or questionnaires were used to investigate hospitalized adolescents with depressive episodes and their mothers and healthy adolescents and their mothers.In patients with adolescent depressive episodes,the amygdala was selected as the region of interest to compare whole-brain resting-state functional connectivity in offspring of mothers with and without childhood trauma.Results(1)The physical neglect scores,emotional abuse scores,emotional neglect scores,anxiety and depression scores of mothers in the depressive episode group were significantly higher than those of mothers in the healthy group,the dif-ference was statistically significant(P＜0.05).(2)Among the adolescents with depressive episodes,there were no significant differences in anxiety scores and childhood trauma factor scores and its total scores between the group whose mothers suffered childhood trauma and the group whose mothers did not suffer childhood trauma(P＞0.05).(3)In adolescents with depressive episodes,offspring with maternal childhood trauma had reduced values of functional con-nectivity between the amygdala as a region of interest and brain regions such as parahippocampal gyrus,lingual gyrus,suboccipital gyrus,suprafrontal gyrus etc,compared to offspring without maternal childhood trauma.Conclusion Maternal childhood trauma and anxiety and depression may increase the risk of depression in offspring,and maternal childhood trauma affects the brain functional network of offspring with the amygdala as the seed point,but maternal childhood trauma does not affect anxiety symptoms and severity of childhood trauma in adolescents with depression.
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