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首发广泛性焦虑障碍患者的焦虑程度与其记忆功能及应激水平的关系

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目的 分析首发广泛性焦虑障碍(Generalized anxiety disorder,GAD)患者焦虑程度与其记忆功能及应激水平的关系.方法 选择2020年10月~2022年12月在我院进行治疗的85例首发GAD患者作为研究对象纳入GAD组,依据广泛性焦虑障碍量表(GAP-7)评分结果分为轻度焦虑组(n=28)、中度焦虑组(n=36)、重度焦虑组(n=21).比较三组记忆功能及应激水平[皮质醇(Cortisol,Cor)、C 反应蛋白(c-reactive protein,CRP)、白介素 6(Interleukin 6,IL-6)]、不同焦虑程度 GAD患者记忆功能及应激水平,采用Spearman秩相关分析首发GAD患者焦虑严重程度与记忆功能、应激水平相关性.结果 三组Cor、CRP、IL-6、总延迟反应时间及无延迟反应时间比较,重度焦虑组>中度焦虑组>轻度焦虑组,三组总延迟正确数、无延迟正确数比较,重度焦虑组<中度焦虑组<轻度焦虑组(P<0.05);相关性分析显示,首发GAD患者Cor、CRP、IL-6、总延迟反应时间及无延迟反应时间与焦虑严重程度呈正相关,总延迟正确数、无延迟正确数与焦虑严重程度呈负相关(P<0.05).结论 GAD患者的应激水平、记忆功能与患者焦虑严重程度关系密切,随着患者焦虑程度加重,患者应激炎症因子水平逐渐升高,但记忆功能持续减退.
The relationship between anxiety level and memory function,stress level in patients with first-episode gen-eralized anxiety disorder
Objective Analyze the relationship between anxiety levels,memory function,and stress levels in patients with first episode generalized anxiety disorder(GAD).Methods Choose in October 2020 to December 2022 in our hospital for treatment of 85 patients with first GAP as the research object into the GAD group,on the basis of generalized anxiety disorder scale(GAP-7)score results were divided into mild anxiety group(n=28),moderate anxiety group(n=36),severe anxiety group(n=21).Compare two groups of memory function and stress levels[cortisol(Cor),c-reactive protein(CRP)and interleukin 6(IL-6)]and memory function in patients with different degree of anxiety GAD and stress level,the Spearman rank correlation analysis starting anxiety severity and memory function in patients with GAD,stress level correlation.Results Three groups of Cor,CRP,IL-6,the total delay time and no delay reaction time,high severe anxiety>moderate anxiety grou P>mild anxiety groups,three groups to the total number of delay right,without delay,the correct number,high severe anxiety<moderate anxiety grouP<mild anxiety group(P<0.05);Correlation analysis showed that the starting GAD patients with Cor,CRP,IL-6,the total delay time and no delay reaction time was positively correlated with anxiety severity,the total number of delay right,without delay,the correct number and negatively correlated with anxiety severity(P<0.05).Conclusion The stress level and memory function of GAD patients are closely related to the severity of anxiety.With the aggravation of anxiety,the levels of stress inflammatory factors gradually increase,but the memory function continues to decline.

Generalized anxiety disorderMemory functionStress levelCortisol

石慧、吴瑛、马胤

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上海交通大学医学院附属精神卫生中心(上海,200030)

广泛性焦虑障碍 记忆功能 应激水平 皮质醇

2024

国际精神病学杂志
中南大学

国际精神病学杂志

CSTPCD
影响因子:1.426
ISSN:1673-2952
年,卷(期):2024.51(3)
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