rTMS仪联合艾司西酞普兰对门诊焦虑障碍患者焦虑症状、睡眠质量及认知功能的疗效研究
Effect of rTMS combined with escitalopram on anxiety symptoms,sleep quality and cognitive function in outpatients with anxiety disorder
刘飞 1张明园 2张晨 2施慎逊 3范毅敏 2高志勤 4汪卫华 4程祺 4曹志永 4张毅 2陆峥1
作者信息
- 1. 同济大学附属同济医院精神医学中心(上海 200065)
- 2. 上海交通大学医学院附属精神卫生中心
- 3. 复旦大学附属华山医院精神医学科
- 4. 中国人民解放军联勤保障部队第904医院心理科
- 折叠
摘要
目的 验证家用便携式重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗仪(PLTK-Home)治疗门诊焦虑障碍患者的有效性与安全性.方法 采用开放对照研究,456例焦虑障碍患者分配为rTMS治疗组211例与对照组245例.两组均给予艾司西酞普兰治疗.治疗前后采用汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)、匹茨堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)、重复性神经心理状态测验(Repeatable Battery for the Assessment of Neuropsychological Status,RBANS)评定临床症状.结果 419例患者完成4周随访,rTMS组192例,对照组227例,两组患者治疗4周后HAMA减分值(rTMS组:-19.23±4.19;对照组:-13.6 0±5.17)、PSQI减分值(rTMS组:-11.75±3.11;对照组:-6.73±4.74)评分结果均显著下降;RBANS评分结果显示rTMS组患者经过4周治疗注意评分显著提高(rTMS组:8.51±7.13),而对照组未发现明显变化;组间比较显示采用重复测量资料的方差分析,rTMS组患者经过4周治疗后HAMA、PSQI、RBANS注意评分相比对照组改善更为显著(P＜0.05).结论 便携式rTMS治疗仪能改善焦虑障碍患者的焦虑症状与睡眠症状,为焦虑障碍患者提供了新的一种便于普及的家用治疗方式.
Abstract
Objective To evaluate the efficacy and safety of portable repetitive transcranial magnetic stimulation(rTMS)instrument(PLTK-Home)in the treatment of anxiety disorders in outpatients.Methods 456 patients with anxiety disorder were divided into rTMS group(n=211)and control group(N=245).Both groups were treated with escitalopram.Before and after treatment,the clinical symptoms were assessed with Hamilton Anxiety Scale(HAMA),Pittsburgh Sleep Quality Index(PSQI)and Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).Results A total of 419 patients completed the 4-week study.There were 192 ones in rTMS and 227 ones in control groups,respectively.After 4 weeks of treatment,decreasing scores of HAMA(rTMS group:-19.23±4.19,control group:-13.60±5.17)and decreasing scores of PSQI(rTMS Group:-11.75±3.11,control group:-6.73±4.74)were significantly in both groups.The results of RBANS showed that the attention score of the patients in the rTMS group increased significantly after 4 weeks of treatment(rTMS group:8.51±7.13),while no significant change was found in the control group;after 4 weeks of treatment,the scores of HAMA,PSQI and RBANS in the rTMS group improved more significantly than those in the control group(P＜0.05).Conclusion The portable rTMS therapeutic instrument can improve the anxiety and sleep symptoms of the patients with anxiety disorders,and provide a new convenient and popular home therapy for the patients with anxiety disorders.
关键词
重复经颅磁刺激/焦虑/睡眠/认知功能Key words
Repetitive transcranial magnetic stimulation/Anxiety/Sleep/Cognitive function引用本文复制引用
基金项目
上海市"科技创新行动计划"医学创新研究专项(21Y21900700)
出版年
2024
NETL
NSTL
万方数据