摘要
目的 分析酒精依赖患者戒断早期认知障碍情况及危险因素.方法 回顾性分析2021年6月～2023年6月在我院进行治疗的128例酒精依赖症的临床资料.依据简易精神状况量表(Mini Mental State Examination,MMSE)评估结果将其分为认知障碍组(n=53)、无认知障碍(n=75).比较两组基线资料、认知功能[空间广度(space span,SS)、数字广度(digit sequence,DS)、语言记忆(hopkins verbal learning test,HVLT)、视觉空间记忆(brief visuospatial memory test,BVMT)],采用多因素Logistic回归分析酒精依赖患者戒断早期认知障碍的影响因素,采用ROC分析日均饮酒量、饮酒年限、SS、HVLT预测酒精依赖患者戒断早期认知障碍的价值.结果 认知障碍组日均饮酒量、饮酒年限、吸烟史占比、睡眠障碍占比均高于无认知障碍组,SS及HVLT低于无认知障碍组(P＜0.05);多因素Logistic回归分析证实,日均饮酒量、饮酒年限、吸烟史、睡眠障碍、SS、HVLT均为酒精依赖患者戒断早期认知障碍的危险因素(P＜0.05);经ROC分析证实,日均饮酒量、饮酒年限、SS、HVLT均可用于预测酒精依赖患者戒断早期认知障碍的发生,曲线下面积分别为0.801、0.702、0.806、0.813(P＜0.05).结论 戒断早期酒精依赖患者认知障碍发生率较高,引发认知障碍的危险因素较多,包括日均饮酒量、饮酒年限、吸烟史、睡眠障碍、SS、HVLT,可结合以上因素进一步筛查高危患者,及时采取预防措施,提高戒断成功率.
Abstract
Objective To analyze the status and risk factors of early cognitive impairment in patients with alcohol dependence.Methods A retrospective analysis from June 2021 to June 2023 in our hospital for treatment of the clini-cal data of 128 patients with alcohol dependence.According to the results of Mini Mental State Examination(MMSE),they were divided into cognitive impairment group(n=53)and no cognitive impairment group(n=75).Baseline data,cognitive function[space span(SS),digit span(digit sequence(DS)),verbal memory(hopkins verbal learning test,HVLT),brief visuospatial memory test(BVMT)].Multivariate Logistic regression was used to analyze the influenc-ing factors of early cognitive impairment in patients with alcohol dependence.The ROC analysis daily drinking,drink-ing age,SS,HVLT predict early cognitive impairment in patients with alcohol dependence withdrawal value.Results Compared with the non-cognitive impairment group,the cognitive impairment group had significantly higher daily alcohol consumption,drinking years,proportion of smoking history,and proportion of sleep disorders,and signifi-cantly lower SS and HVLT(P＜0.05).Multivariate Logistic regression analysis confirmed that daily alcohol consump-tion,drinking years,smoking history,sleep disorders,SS,HVLT were risk factors for early cognitive impairment in patients with alcohol dependence(P＜0.05).Confirmed by ROC analysis,average daily drinking,drinking age,SS,HVLT all can be used to predict early cognitive impairment in patients with alcohol dependence withdrawal,the area under the curve were 0.801,0.702,0.806,0.813,both P＜0.05.Conclusion Withdrawal with a greater incidence of early cognitive disorder in patients with alcohol dependence,triggering a risk factor for cognitive impairment,in-cluding fixed number of year of the average daily drinking,drinking,smoking,sleep disorder,SS,HVLT,further screening high-risk patients can be combined with the above factors,take timely preventive measures,improve the success rate of withdrawal.
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