非器质性睡眠障碍患者工作记忆与认知损伤相关性
The correlation of working memory and cognitive function in patients with nonorganic insomnia
褚贝贝 1朱文礼1
作者信息
- 1. 芜湖市第四人民医院精神科(芜湖,241007)
- 折叠
摘要
目的 探讨非器质性睡眠障碍(Nonorganic insomnia,NI)患者与健康对照组(Health controls,HC)的工作记忆与认知功能的相关性.方法 本研究纳入50例NI患者及50例HC被试;采用N-back任务进行评估工作记忆;采用词汇流畅性、数字符号替换、连线测试、Stroop色词测试评估两组认知功能,比较NI组与HC组认知功能差异,并探讨工作记忆与认知功能相关性.结果 NI组[(1520.18±110.23)ms;(2255.15±409.88)ms]在2-back 和3-back任务反应时大于HC 组[(1376.10±165.91)ms;(1873.39±208.07)ms],均差异有统计学意义(P＜0.05);相较于 HC组[(12.68±3.16)s,(38.36±5.23)分,(99.68±22.04)s,(5.28±1.38)s],NI组[(11.44±2.73)s,(35.40±6.63)分,(109.14±24.56)s,(9.56±1.31)s]在词汇流畅性、数字符号替换、连线测试-B、数字符号替换、Stroop抗干扰反应时较差,均差异有统计学意义(P＜0.05),NI组3-back测试反应时与数字符号替换呈负相关(r=-0.363,P=0.010),与连线测试A和B呈正相关(r=0.379,P=0.007;r=0.314,P=0.027).结论 NI患者存在工作记忆和认知功能的异常,工作记忆损伤与认知功能密切相关.
Abstract
Objective To explore the correlation of working memory and cognitive function between nonorganic insomnia(NI)patients and health controls(HC).Methods A total of 50 NI patients were compared with matched 50 HC.Working memory of all the subjects were assessed by N-back test.Cognitive function of all the subjects were assessed by verbal fluency、digital symbol substitution、Trail Making Test、Stroop color word testing,Comparison the correla-tion between working memory and cognitive function in NI group.Results The reaction time of 2-back and 3-back test in NI group[(1520.18±110.23)ms;(2255.15±409.88)ms]were higher than HC group[(1376.10±165.91)ms;(1873.39±208.07)ms](All,P＜0.05).Compared with HC group[(12.68±3.16)s,(38.36±5.23)score,(99.68±22.04)s,(5.28±1.38)s],NI group[(11.44±2.73)s,(35.40±6.63)score,(109.14±24.56)s,(9.56±1.31)s]showed significantly impaired in performance of verbal fluency、digital symbol substitution、Trail Making Test-B、anti-interference reaction time of Stroop task(All,P＜0.05).The reaction time of 3-back test in NI group was negatively cor-related with Digital symbol substitution in NI group(r=-0.363,P=0.010),but positively correlated with Trail Making Test-A and B(r=0.379,P=0.007;r=0.314,P=0.027).Conclusion The studies find working memory and cognitive function in early NI was impaired,and cognitive function impairment is closely related to working memory.
关键词
睡眠障碍/记忆/认知Key words
Insomnia/Memory/Cognitive引用本文复制引用
基金项目
安徽省卫健委科研项目(AHWJ2022b096)
安徽省重点研究与开发计划项目(202204295107020065)
出版年
2024
NETL
NSTL
万方数据