Effect of paroxetine on improving mood and cognition in patients with intracranial infection and anxiety and depression after craniocerebral injury
Objective To study the effects of paroxetine on emotional state,cognitive function and quality of life in patients with intracranial infection and anxiety and depression after craniocerebral injury.Methods A total of 90 patients with intracranial infection accompanied by anxiety and depression after craniocerebral injury surgery in the Department of Neurosurgery of our hospital from June 2020 to June 2022 were randomly assigned,45 patients in the control group received conventional treatment,and 45 patients in the observation group received combined treatment with paroxetine.Indicators of intracranial infection,emotional state,cognitive function,quality of life and adverse reactions were compared between the two groups.Results There was no significant difference in the levels of leuko-cyte,protein and glucose in cerebrospinal fluid between the two groups after treatment(P＞0.05).After treatment,the Hamilton Anxiety Scale and Hamilton Depression Scale scores in the observation group were lower than those in the control group(P＜0.05).After treatment,the neurological deficit score in the observation group was lower than that in the control group,and the score on the Montreal Cognitive Function Assessment Scale was higher than that in the con-trol group(P＜0.05).After treatment,the scores of material function,social function,psychological function,and physical function in the observation group were higher than those in the control group(P＜0.05).There was no statis-tically significant difference in the total incidence of adverse reactions between the two groups of patients(P＞0.05).Conclusion Combined treatment with paroxetine can effectively improve the emotional state of patients with intracra-nial infection and anxiety and depression after craniocerebral injury,promote the recovery of cognitive function,im-prove the quality of life,and have high safety.
Intracranial infectionParoxetineEmotional stateCognitive function
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