A Randomized Controlled Study on the Development and Outcome of Family Social Behavior Interven-tion in Infants and toddlers with Familial High Risk Autism Spectrum Disorder
Objective Uncovering the effects of a family social behavior intervention on social behavior,neu-rodevelopmental trajectories,and outcomes in infants and toddlers with familial high-risk autism spectrum disorder(ASD).Method One hundred and ten familial high-risk ASD infants(young siblings of children with ASD)aged 6 months old recruited in the Department of Child Rehabilitation of Qingyuan Maternal and Child Health Hospital were used as the study group,and 58 familial low-risk ASD infants(young siblings of normal-developing children)aged 6 months old were recruited in the Department of Children's Group Health Care at the same period of time were used as controls.The study group was divided into Study Group A and Study Group B according to random number table method.Study Group A was treated with family social behavioral intervention,while Study Group B and control group were treated with conventional parenting methods and followed up until 24 months of age.At 6,12 and 18 months of age,the study group and the control group were assessed by the autism observation scale for infants(AOSI)and the gesell developmental scale(GDS),respectively,for social behavior and neurodevelopmental functioning.At 24 months of age,the neurodevelopmental and core symptoms of ASD were assessed using the GDS and the Childhood Autism Scale,and the developmental outcomes of the three groups were judged according to the relevant diagnostic criteria in the Diag-nostic and Statistical Manual of Mental Disorders(5th edition).Results In intra-group comparison,the AOSI total score and GDS scores in each functional area of the three study groups were linearly related to the time of assessment,and the differences were statistically significant when comparing the scores at different time points(P＜0.05).In inter-group comparison,the AOSI total scores and the GDS scores in each functional area of the three study groups were bet-ter for the control group than for study group A,and study group A was better for study group B,and the differences were statistically significant(P＜0.05).The proportion of children diagnosed with ASD at the age of 2 in the control group was 1.7％,with language disorders being 1.7％,high-risk children with ASD being 1.7％,and 3 cases(5.2％)of language and behavior abnormalities;The proportion of children diagnosed with ASD in study group A at the age of 2 was 5.5％,with language disorders being 5.5％,high-risk children with ASD being 3.6％,and a total of 8 cases(14.5％)with abnormal language and behavior;The proportion of children diagnosed with ASD in study group B at the age of 2 was 16.4％,language disorders were 18.2％,high-risk children with ASD were 5.5％,and a total of 22 cases(40％)had abnormal language and behavior.Conclusion Compared with children with familial low-risk ASD,children with familial high-risk ASD have more ASD-like behaviors in infancy and childhood,and their neurodevelop-ment is relatively backward;they are more likely to develop ASD or have different degrees of language-behavior prob-lems.Family social behavior intervention from infancy can effectively promote language-social behavior development and neurodevelopment in children with familial high-risk ASD,thereby reducing the incidence of ASD or language-behavior abnormalities.
Family social behavior interventionInfants and children with familial high-risk autism spectrum disordersDevelopmentOutcome
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