Analysis of the correlation between clinical symptoms and inflammatory factors in first-episode unmedi-cated schizophrenia
Objective To investigate and analyze the relationship between clinical symptoms and inflammatory factors in first-episode unmedicated schizophrenia.Methods Seventy-six participants were recruited and divided into a group of patients with first-episode unmedicated schizophrenia and a healthy control group.Serum inflammatory fac-tor levels were tested for all subjects,and patient sociodemographic data,Positive and Negative Symptom Scale scores(PANSS),and Brief Psychiatric Rating Scale scores(BPRS)scale scores were also collected.We compared the dif-ferences in inflammatory factor levels between the two groups,analyzed the correlation between the different inflamma-tory factors and clinical symptoms,and used ROC curves to analyze the diagnostic value of inflammatory factor levels for schizophrenia.Results The levels of IL-1β,IL-4,bFGF,IL-13,IL-8,IP-10,and MCP-1 were significantly higher(P＜0.05),and the levels of VEGF-D were lower(P＜0.05)in the study group compared to healthy controls.It was also found that IL-1β,MCP-1,and IL-13 were correlated with PANSS scale,BPRS scale,and their subscales(all P＜0.05).Finally,bFGF(AUC=0,9944)was found to be a serum inflammatory factor with better diagnostic ef-ficacy by ROC curve analysis.Conclusion Serum inflammatory factor is closely related to schizophrenia and is also of high value in the diagnosis of first-episode unmedicated schizophrenia.
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