Relationship between Levels of Non-enzymatic antioxidants and Aggressive Behavior in Patients with Acute Schizophrenia
Objective To explore relationship between levels of non-enzymatic antioxidants and aggressive be-havior in patients with acute schizophrenia.Methods A total of 112 patients with acute schizophrenia were enrolled,including 77 patients in non-aggressive group and 85 patients in aggressive group.General social data of patients were collected by self-made questionnaire,clinical symptoms were assessed by the Positive and Negative Symptom Scale,aggressive behavior were assessed by the Modified Overt Aggression Scale,and non-enzymatic antioxidants levels were detected by fully automated biochemical analyzer.The relationship between levels of non-enzymatic antioxidants and ag-gressive behavior were statistically analyzed.Results The positive symptom score in the aggressive group was higher than that in the non-aggressive group(P＜0.05),while the levels of total bilirubin(TBIL),direct bilirubin,and indirect bilirubin in the aggressive group were higher than those in the non-aggressive group(P＜0.05).Gender,use clozap-ine,TBIL,and positive symptom score are the influencing factors of aggressive behavior in patients with acute schizo-phrenia,and high TBIL level having the most significant impact(OR=1.275,P＜0.001).Conclusion There are some changes in levels of non-enzymatic antioxidants in patients with acute schizophrenia accompanied by aggressive behavior,the difference in bilirubin level is particularly significant,and high TBIL level is a risk factor for aggressive behavior.
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