Comparative study of different doses of sertraline combined with ziprasidone in treatment of schizo-phrenic patients with depressive symptoms
Objective To explore the rational dosage of sertraline combined with ziprasidone in schizophrenic patients with depressive symptoms.Methods 160 patients with schizophrenia and depressive symptoms were selected from May 2018 to May 2021 and divided into group A according to simple random sampling method(n=60),group B(n=50)and group C(n=50).Group A was treated with low-dose sertraline combined with low-dose ziprasidone,Group B with low-dose sertraline combined with conventional ziprasidone,and Group C with conventional sertraline combined with low-dose ziprasidone for 3 months.The changes of clinical symptoms,depression level,cognitive function and quality of life before and after treatment,and count the occurrence of adverse drug reactions among three groups were compared.Results After treatment,the scores of MoCA and WHOQOL-BREF in group A were signifi-cantly higher than those in group B and group C(P＜0.05).The scores of PANSS and HAMD in group A were signifi-cantly lower than those in group B and group C(P＜0.05).There was no significant difference in the scores of PANSS,HAMD,MoCA,WHOQOL-BREF and the occurrence of adverse drug reactions among the patients in group B and group C(P＞0.05).Conclusion The combination of low-dose sertraline and low-dose ziprasidone can be better to improve the clinical symptoms and depression level of schizophrenic patients with depressive symptoms,and improve their cognitive function and quality of life.
NETL
NSTL
万方数据
