Correlation and mediation effect of serum CRP level and cognitive function in major depression patients with obesity
Objective To analyze the relationship between serum C-reactive protein(CRP)level and cogni-tive function in patients with major depressive disorder(MDD)and obesity,and to explore whether serum CRP has a mediating effect between BMI and cognitive function.Methods A total of 82 MDD patients admitted to Weifang Men-tal Health Center from December 2022 to June 2023 were selected,and divided into two groups according to whether they were accompanied by obesity,40 in the observation group(combined with obesity)and 42 in the control group(without obesity).Serum CRP levels were detected in the two groups,respectively.The Hamilton Depression Scale(HAMD-17)was used to assess the degree of depression,and the Chinese version of the Montreal Cognitive As-sessment Scale(MoCA)was used to assess the cognitive function of the patients.The correlation between serum CRP level and cognitive function in the observation group was analyzed,and the mediating effect of serum CRP on BMI and cognitive function was explored.Results The serum CRP level in the observation group was higher than that in the control group(P＜0.05),and the total score of MoCA,visuospatial executive function and delayed recall score in the observation group were lower than those in the control group(P＜0.05).Serum CRP level was significantly negatively correlated with MoCA total score,visuospatial executive function,attention and delayed recall score(P＜0.05).The results of mediation effect analysis showed that serum CRP played a partial mediating role between BMI and delayed re-call.Conclusion The serum CRP level of MDD patients with obesity is higher than that of MDD patients without obe-sity.The serum CRP level is negatively correlated with cognitive function,and may partially mediate the relationship between BMI and delayed recall.
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