Efficacy of Non Convulsive Electroconvulsive Therapy for Severe Depression and Its Impact on Se-rum Levels of BDNF and Inflammatory Factors
Objective To explore the efficacy of modified electroconvulsive therapy(MECT)in the treatment of severe depression and its influence on the levels of serum Brain-derived neurotrophic factor(BDNF)and inflammatory factors.Methods 84 patients with severe depression from February 2021 to January 2023,and they were randomly divided them into two groups using a numerical table method.42 patients in the control group were treated with Parox-etine,and 42 patients in the observation group were treated with MECT on the basis of the control group.The Hamilton Anxiety,Depression Scale(HAMA,HAMD),as well as serum BDNF and interleukin-1 levels,Interleukin-1 and IL-10 level between two groups before and after treatment were compared.Results After treatment,the HAMA score and HAMD score of both groups of patients were significantly reduced,and the observation group had significantly lower scores than the control group(P＜0.05).After treatment,the serum levels of BDNF and IL-10 in both groups of pa-tients significantly increased,the IL-β levels were significantly reduced,and the changes in various indicators in the observation group were better than those in the control group after treatment(P＜0.05).Conclusion MECT treatment for severe depression can reduce anxiety and depressive emotions,increase serum BDNF levels,and regulate inflam-matory factor levels.
Non convulsive electroconvulsive therapySevere depressionBrain-derived neurotrophic factorInflammatory factor
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