Objective To explore the level and clinical significance of serum folate,Brain-derived neurotrophic factor(BDNF)and 25 hydroxyvitamin D[25 hydroxyvitamin D,25(OH)D]in children with autism.Methods Eighty children with autism from February 2019 to February 2023 were selected as the research subjects.The autistic children were set as the observation group,and 80 matched normal children with general information were set as the control group.The levels of serum folate,BDNF,and 25(OH)D between two groups were compared.According to the Child Autism Rating Scale(CARS),the observation group was divided into mild to moderate group and severe group.The serum indicator levels and CARS scores of children with different severity of illness were compared.The correla-tion between serum indicator levels and CARS scores were analyzed.Results The levels of serum folate and 25(OH)D in the observation group were significantly lower than those in the control group,while the levels of BDNF were sig-nificantly higher than those in the control group(P＜0.05).The serum folate and 25(OH)D levels in the severe group were significantly lower than those in the mild to moderate group,while the CARS score and BDNF levels were signifi-cantly higher than those in the mild to moderate group(P＜0.05).Serum folate and 25(OH)D levels in children with autism were negatively correlated with CARS scores,while BDNF levels were positively correlated with CARS scores(P＜0.05).Conclusion The serum levels of folic acid and 25(OH)D in children with autism decrease,while BDNF levels increase,which are significantly correlated with the severity of autism.
AutismFolic acidBrain-derived neurotrophic factorVitamin D
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