Effect of Sertraline and paroxetine on obsessive-compulsive disorder and the level of brain-derived neu-rotrophic factor
Objective The effects of sertraline hydrochloride and paroxetine on cognitive function and brain-derived neurotrophic factor in the treatment of obsessive-compulsive disorder(OCD)were analyzed to provide reference for the relevant intervention measures for the recovery of cognitive function in patients with OCD.Methods A total of 100 patients with OCD admitted to the psychiatric department of our hospital from April 2021 to April 2023 were selected by case sampling method,including 50 patients in the sertraline hydrochloride group and 50 patients in the Paxil group;The subjects were assessed with the Alyes-Brown scale for obsessive-compulsive disorder and the Loewenstein Cogni-tive function rating Scale for cognitive function.The presence of BDNF-mRNA in samples was detected by PCR,and the expression products of BDNF-mRNA were quantitatively analyzed by bioinformatics platform.Results After one course of treatment,the scores of ALYes-Brown scale in all obsessive-compulsive disorder patients in sertraline hydrochloride group and paroxetine group were significantly decreased(P＜0.05),and the expression level of BDNF-mRNA was in-creased(P＜0.05),and the changes in sertraline hydrochloride group were more significant than those in paroxetine group(P＜0.05).In addition,there was no statistical difference in all cognitive function scores between Sertraline hydrochlo-ride group and paroxetine group before intervention(P＞0.05),so it was considered that the scores of the two groups after intervention were comparable.In Sertraline hydrochloride group,the scores of geometric pattern recognition,pattern overlap recognition,item consistency recognition,spatial relationship with surrounding objects and spatial relationship in pictures were significantly increased after intervention compared with those before intervention(P＜0.05).After the in-tervention,the scores of geometric figure recognition and spatial relation in pictures in paroxetine group were significantly increased compared with those before the intervention(P＜0.05).Sertraline hydrochloride group improved the scores of geometric pattern recognition,pattern overlap recognition,item consistency recognition and spatial relation in pictures more significantly than paroxetine group(P＜0.05).Conclusion Sertraline hydrochloride is slightly more effective than paroxetine in the treatment of obsessive-compulsive disorder,and sertraline hydrochloride can better maintain the cogni-tive function of patients and improve the level of brain-derived neurotrophic factor.
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