目的 观察丁苯酞治疗阿尔茨海默病(Alzheimer's disease,AD)精神行为症状(Behavioral and psychological symptoms,BPS)的疗效.方法 数字表随机法对2021年2月～2023年5月84例AD合并BPS患者随机分组,对照组采用利培酮治疗,观察组联合丁苯酞治疗,比较两组患者治疗前后认知功能、生活能力、BPS以及不良反应的差异.结果 治疗后两组认知功能、生活能力评分均上升,且观察组治疗后这2项评分更高(P＜0.05);治疗后两组AD行为病理学评定量表(Behavioral pathology in AD rating scale,BEHAVE-AD)、神经精神症状问卷中文版(Neuropsychiatric inventory Chinese,CNPI)评分均下降,且观察组治疗后这2项评分更低(P＜0.05);两组治疗1个月、3个月副反应量表(treatment emergent symptom scale,TESS)评分差异无统计学意义(P＞0.05).结论 丁苯酞治疗AD合并BPS不仅能提升患者的认知功能与生活能力,还能减轻BPS,且用药安全.
Observation on the Therapeutic Effect of Butylphthalide in the Treatment of Psychiatric and Behavioral Symptoms of Alzheimer's Disease
Objective The therapeutic effect of butylphthalide in the treatment of behavioral and psychologi-cal symptoms(BPS)in Alzheimer's disease(AD)were observed.Methods Eighty-four AD patients with BPS from February 2021 to May 2023 were randomly grouped using the digital table method.The control group was treated with risperidone,while the observation group was treated with a combination of butylphthalide.The differences of cognitive function,life ability,BPS,and adverse reactions of two groups of patients before and after treatment were compared.Results After treatment,the cognitive function and life ability scores of both groups increased,and the observa-tion group had higher scores in both items after treatment(P＜0.05).After treatment,the scores of both groups of AD behavioral pathology in AD rating scale(BEHAVE-AD)and neuropsychiatric inventory Chinese version(CNPI)decreased.The observation group had lower scores in both items after treatment(P＜0.05).There was no statistically significant difference in the treatment emergency symptom scale(TESS)scores between the two groups after 1 and 3 months of treatment(P＞0.05).Conclusion The treatment of AD combined with BPS with butylphthalide can not only improve the cognitive function and life ability of patients,but also reduce BPS,and the medication is safe.
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