Effect of citalopram combined with mirtazapine on Parkinson's disease patients with depression
Objective To explore the clinical efficacy of using mirtazapine in the treatment of Parkinson's dis-ease(PD)patients with depression.Methods Case data were collected and filed from September 2019 to Septem-ber 2022.The subjects were PD patients with depression admitted to the hospital,with a total of 80 cases included.The subjects were divided into a control group(treated with citalopram)and an observation group(treated with citalopram+mirtazapine)based on a 1:1 random number table method,with 40 cases in each group;Observe and com-pare the levels of anxiety and depression,sleep quality,Unified Parkinson's Disease Rating Scale(UPDRS Ⅲ),daily living ability,and incidence of adverse reactions between two groups.Results After treatment,the Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)scores of both groups decreased,and the observation group had lower scores(P＜0.05).After treatment,the Pittsburgh Sleep Quality Index(PSQI)scores of both groups were significantly reduced,and the observation group had significantly lower PSQI scores than the control group(P＜0.05).After treatment,the UPDRS Ⅲ scores of both groups decreased,and the Activities of Daily Living(ADL)scores in-creased.The observation group performed better than the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The use of citalopram combined with mirtazapine in the treatment of PD patients with depression can exert good antidepressant effects,improve sleep quality,improve their psychological state,and have good medication safety.
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