目的 分析艾司氯胺酮对产妇剖宫产术后应激与产后抑郁发生情况的影响.方法 将2021年3月～2023年3月间在本院行剖宫产手术的108例产妇纳为研究对象,将产妇按照随机数字表法分为对照组、观察组,每组54例.对照组产妇术后采用布托啡诺进行自控静脉镇痛治疗,观察组产妇术后加用艾司氯胺酮进行自控静脉镇痛治疗.观察产妇术后相关应激反应评价变化与产后抑郁的发生情况.结果 观察组产妇产后不同时间点的视觉模拟评分法(visualanaloguescale,VAS)评分均低于对照组,且患者产后1周的产后抑郁发生率更低(P＜0.05).两组产妇产后不同时间的简易智力状态检查量表(mini-mental state examination,MMSE)评分与不良反应发生情况均无明显差异(P＞0.05).结论 艾司氯胺酮对于减轻剖宫产产妇产后疼痛具有良好表现,有助于缓解产妇的术后应激反应,降低产后抑郁的发生风险.
The effect of esketamine on the incidence of stress and postpartum depression after Caesarean section
Objective To analyze the effect of esketamine on stress and postpartum depression after Caesarean section.Methods 108 pregnant women who underwent Caesarean section in our hospital from March 2021 to March 2023 were enrolled as the study subjects.The pregnant women were divided into control group and observation group according to random number table,with 54 cases in each group.The patients in the control group were treated with butorphanol for PCIA after operation,and the patients in the observation group were treated with esketamine for PCIA after operation.The changes in postpartum stress response evaluation and the occurrence of postpartum depression in postpartum women after surgery were compared between two groups.Results The visual analog scale(VAS)scores of postpartum women in the observation group were lower than those in the control group at different time points,and the incidence of postpartum depression was lower in patients after one week postpartum(P＜0.05).There was no significant difference in the scores of the mini mental state examination(MMSE)and the incidence of adverse reactions between the two groups of postpartum women at different times(P＞0.05).Conclusion Esketamine has a good performance in relieving postpartum pain of parturients after Caesarean section,which is helpful to alleviate the stress reaction of par-turients after operation and reduce the risk of postpartum depression.
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