Effect of escitalopram on poststroke depression patients and its effect on brain-derived neurotrophic factor
Objective To investigate the effect of escitalopram on patients with poststroke depression(PSD)and its effect on brain-derived neurotrophic factor(BDNF).Methods A total of 90 patients with PSD admitted from Feb-ruary 2019 to September 2022 were selected as the research objects and divided into psychological group and drug group according to the intervention method,45 cases in each group.Both groups received basic symptomatic treatment,the psychological group received psychological intervention,and the drug group was treated with escitalopram.Depressive mood,neurological function,quality of life,quality of sleep and the occurrence of adverse reactions were compared between the two groups.Results After 8 weeks of intervention,the scores of Hamilton Depression Scale(HAMD)and National Institutes of Health Stroke Scale(NIHSS)in both groups were lower than before intervention,and the drug group was lower than the psychological group.The level of BDNF in drug group was higher than that in psychological group(P＜0.05).After 8 weeks of intervention,Barthel index(BI)score in both groups was higher than that before intervention,and that in drug group was higher than that in psychological group.Pittsburgh Sleep Quality Index(PSQI)score was lower than that before intervention,and the drug group was lower than the psychological group(P＜0.05).By Fisher's exact probability test,there was no difference in the incidence of adverse reactions between the drug group(8.89％)(4/45)and the psychological group(4.44％)(2/45)(P＞0.05).Conclusion Escitalopram can regulate the neurological function of PSD patients,improve their quality of life and sleep,regulate depression,and has good safety.
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