舍曲林对脑出血合并抑郁患者抑郁状态及神经功能的影响
Effect of Sertraline on depressive state and neurological function in patients with cerebral hemorrhage complicated with depression
加艳 1杜培培 1李珊 1石鹏 1董静 1贺婵婵1
作者信息
- 1. 延安大学咸阳医院(咸阳,712000)
- 折叠
摘要
目的 研究舍曲林对脑出血合并抑郁患者抑郁状态及神经功能的影响.方法 选取本院2021年2月～2023年2月期间90例脑出血合并抑郁患者采用随机数字表法分组,两组患者均接受脑出血常规治疗,对照组45例给予常规心理疏导和安慰剂治疗,观察组45例给予常规心理疏导联合舍曲林治疗,对比两组患者抑郁情绪、神经功能、相关因子水平和不良反应.结果 观察组治疗后,汉密尔顿抑郁量表评分低于对照组(P＜0.05);观察组治疗后,神经功能缺损评分低于对照组,Barthel指数高于对照组(P＜0.05);观察组治疗后,血清神经丝轻链蛋白、磷酸化tau蛋白181水平均低于对照组(P＜0.05);两组患者均未发生明显不良反应.结论 舍曲林能够有效改善脑出血合并抑郁患者抑郁状态,促进患者神经功能恢复,安全性高,具有临床推广价值.
Abstract
Objective To study the effects of sertraline on depressive state and neurological function in patients with cerebral hemorrhage complicated with depression.Methods A total of 90 patients with cerebral hemorrhage com-plicated with depression from February 2021 to February 2023 in our hospital were selected and divided into two groups by random number table method.Both groups received routine treatment for cerebral hemorrhage,45 patients in the control group received routine psychological counseling and placebo treatment,and 45 patients in the observation group received routine psychological counseling combined with sertraline treatment.Depressive mood,neurological function,levels of related factors and adverse reactions were compared between the two groups.Results After treatment,the Hamilton anxiety rating scale(H AMD)score of the observation group was lower than that of the control group(P＜0.05).After treatment,Neurological deficit soore(NIHSS)in observation group was lower than that in control group,and Barthel index(BI)was higher than that in control group(P＜0.05).After treatment,serum levels of Neurofilament light Chain(NfL)and Phosphorylated tau181(P-TAu181)in the observation group were lower than those in the con-trol group(P＜0.05).No obvious adverse reactions occurred in both groups.Conclusion Sertraline can effectively improve the depressive state of patients with cerebral hemorrhage complicated with depression,and promote the recov-ery of neurological function in patients with high safety,and has clinical popularization value.
关键词
脑出血/抑郁症/舍曲林/心理疏导Key words
Cerebral hemorrhage/Depression/Sertraline/psychological counseling引用本文复制引用
出版年
2024
NETL
NSTL
万方数据