Causal relationship between five psychiatric disorders and changes in cortical thickness and surface area:a Mendelian Randomization study
Objectives Two-sample Mendelian randomization was employed to investigate the causal relation-ship between alterations in cortical thickness and surface area and the risk of schizophrenia,bipolar disorder,major depressive disorder,autism spectrum disorder,attention deficit and hyperactivity disorder.Methods The results of Genome-wide Association Studies(GWASs)for schizophrenia,bipolar disorder,major depressive disorder,autism spectrum disorder,attention deficit and hyperactivity disorder,cortical thickness and surface area were downloaded from Psychiatric Genomics Consortium and the UK biobank.Inverse Variance Weighted(IVW)were used as the main results,and supplementary results were calculated using MR-Egger and Simple median analysis methods.In addi-tion,sensitivity analysis was also performed.Results A significant causal relationship was found between the surface area of the left temporal transverse gyrus as exposure and schizophrenia as outcome.(βIVW=-0.158,P＜0.001).Conclusions A unidirectional causal relationship was identified between left transverse temporal gyrus surface area and schizophrenia(left transverse temporal gyrus surface area as exposure).
Mental disordersMendelian randomization analysisGenome wide association studyCerebral cor-tical thickness
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