Serum TNF in adolescent first-episode depression patients-α,Correlation analysis between IL-13 and somatization symptoms
Objective To explore the correlation between serum tumor necrosis factor-α(TNF-α),interleukin-13(IL-13)and somatic symptoms in adolescents with first-episode depression.Methods According to the inclusion and exclusion criteria,120 adolescent first-episode depression patients treated in our hospital from Janu-ary 2022 to January 2023 were selected as the disease group.In addition,90 health examination personnel in the same period were selected as the health group.Fasting 5mL peripheral venous blood was collected from the health and disease groups and left at room temperature for half an hour.Blood was centrifuged at 4000 RPM for 10min,and the supernatant was removed for determination of serum TNF-α and IL-13 levels by enzyme-linked immunosorbent assay.The serum levels of TNF-α and IL-13 were compared between the two groups,and then the serum levels of TNF-α and IL-13 were compared between patients with different somatic symptoms and patients without somatic symptoms according to whether they were accompanied by somatic symptoms.The correlation between the levels of TNF-α,IL-13 and somatization was analyzed.Results The serum levels of TNF-α and IL-13 in the health group were significantly lower than those in the disease group(P＜0.05).Among the participants,99 cases(82.50%)exhibited somatic symptoms.Patients with somatization who experienced insomnia,dizziness,tinnitus,gastrointestinal symptoms,palpitations,sweating,frequent urination,and weight loss showed significantly higher serum levels of TNF-α and IL-13 compared to those without somatic symptoms.Additionally,serum TNF-α levels were significantly positively correlated with dizziness,tinnitus,and sweating,while IL-13 levels were significantly correlated with tinnitus,gastrointestinal symptoms,palpitations,and weight loss.Conclusion In adolescents with first-episode depression,serum levels of TNF-α and IL-13 are elevated,with even higher levels observed in those exhibiting somatic symptoms.TNF-α levels correlate positively with dizziness,tinnitus,and sweating,while IL-13 levels are associated with tinnitus,gastrointestinal symptoms,palpitations,and weight loss.These findings suggest an inflammatory component in depression,especially in patients with somatic manifestations.
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