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文拉法辛对产后抑郁患者情绪、睡眠及认知功能的影响

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目的 探讨产后抑郁患者的治疗中,采用文拉法辛对患者负面情绪、睡眠及认知功能的影响.方法 2021年1月~2022年12月在我院确诊为产后抑郁的80例患者,按照随机数字表法分为两组,40例纳入对照组实施帕罗西汀治疗,40例纳入观察组实施文拉法辛治疗.统计治疗后临床疗效,并就治疗前后患者负面情绪、睡眠状态、认知功能等进行评价.结果 观察组40例患者经文拉法辛治疗后,记录的临床疗效为97.50%,高于对照组(P<0.05);观察组的爱丁堡产后抑郁量表(EPDS)评分低于对照组(P<0.05);观察组的匹兹堡睡眠质量指数(PSQI)评分低于对照组(P<0.05);观察组的蒙特利尔认知评估量表(MoCA)评分高于对照组(P<0.05).结论 在产后抑郁患者的治疗过程中,选择文拉法辛可更好的改善患者情绪,同时可促进其睡眠及认知功能恢复.
Effect of venlafaxine on negative emotion,sleep and cognitive function in patients with postpartum depression
Objective To explore the value of venlafaxine in the control of postpartum depression,and analyze the impact of this program on negative emotion,sleep and cognitive function.Methods 80 postpartum depression pa-tients in our hospital from January 2021 to December 2022 were divided into two groups according to the random number table.40 patients were included in the control group to receive paroxetine treatment,and 40 patients were included in the observation group to receive venlafaxine treatment.The clinical efficacy,negative emotions,sleep status,cogni-tive function before and after treatment between two groups were compared.Results The clinical efficacy in the obser-vation group was 97.50%,which was higher than that in the control group(P<0.05).The EPDS score in the observa-tion group(4.22±0.21)was lower than that in the control group(P<0.05).The PSQI score in the observation group was lower than that in the control group(P<0.05).The MoCA score recorded in the observation group was higher than that in the control group(P<0.05).Conclusion During the treatment of postpartum depression,venlafaxine can significantly improve the depressive state of patients,and promote their sleep and cognitive function recovery.

VenlafaxinePostpartum depressionNegative emotionsSleepCognitive function

程丹、官丹蕊、傅启伟

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海南省安宁医院药剂科(海口,570100)

文拉法辛 产后抑郁 负面情绪 睡眠 认知功能

2024

国际精神病学杂志
中南大学

国际精神病学杂志

CSTPCD
影响因子:1.426
ISSN:1673-2952
年,卷(期):2024.51(5)