Effects of paroxetine combined with cognitive behavioral therapy on psychological stress,cancer-related fatigue and neurotransmitter levels in lung cancer patients received chemotherapy
Objective To explore the application value of paroxetine combined with cognitive behavioral therapy in patients with lung cancer chemotherapy.Methods A total of 108 patients with lung cancer receiving chemotherapy in our hospital from June 2020 to September 2022 were retrospectively selected as the study objects,and were divided into Western medicine group and cognitive group by drawing lots,with 54 cases in each group.The western medicine group was treated with paroxetine,and the cognitive group was added with cognitive behavioral therapy.Psychological stress,cancer-related fatigue and neurotransmitter levels were compared between the two groups.Results After 12 weeks of treatment,the scores of Hamilton Anxiety Scale,Hamilton Depression Scale,physical perception fatigue,behavioral fatigue,cognitive fatigue and emotional fatigue in the cognitive group were lower than those in the western medicine group.The levels of 5-hydroxytryptamine and Brain-derived neurotrophic factor were higher than those in the western drug group(P＜0.05).Conclusion Paroxetine combined with cognitive behavioral therapy can regulate the level of neurotransmitters,improve psychological stress and reduce cancer-induced fatigue in patients with lung cancer chemotherapy.
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