Correlation of serum inflammatory cytokine levels with symptoms and curative effect in patients with schizophrenia
Objective To examine the correlation between serum inflammatory cytokines and clinical symptoms/efficacy in schizophrenia patients.Methods 50 schizophrenia patient hospitalised in Wuhu Hospital of Beijing Anding Hospital affiliated to Capital Medical Universitys(newly admitted or off medication＞4 weeks)and 50 healthy controls were recruited.Serum IL-2,IL-4,IL-8,IL-10,TNF-α were measured before and after 6 weeks of olanzapine treatment.PANSS assessed symptoms.Changes in cytokines and PANSS scores were compared.Correlation between baseline cytokines,PANSS scores,and treatment differences was analyzed using multiple linear regression.Results Pre-treatment,patients had higher IL-10,TNF-α,lower IL-8.Post-treatment,IL-8 increased,IL-10,TNF-αdecreased.IL-2,TNF-α negatively correlated with PANSS;IL-10 positively correlated.TNF-α baseline positively correlated with negative symptom score difference.Multiple linear regression showed TNF-α baseline predicted negative symptom score difference(adjusted R2=0.198,β=0.445,P=0.001).Conclusion In schizophrenia patients,serum inflammatory cytokine levels correlate with symptoms.Olanzapine modulates these cytokines,with TNF-α potentially predicting its efficacy on negative symptoms.
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