Analysis of serum homocysteine levels and related factors in schizophrenic patients by gender
Objective To investigate the serum homocysteine(Hcy)levels and related risk factors in patients with schizophrenia by gender,and to provide effective prevention and treatment of high-risk populations.Method Schizophrenic patients hospitalized at the Second Affiliated Hospital of Xinxiang Medical College from January 2021 to December 2021 were selected as the study subjects.General demographic data,clinical characteristics and biochemi-cal indexes such as Hcy,blood lipid,and renal function were collected retrospectively by reviewing medical records.According to the level of Hey,the study subjects were divided into HHcy group and non-HHcy group,and the clinical characteristics of the two groups were compared according to gender.Multivariate Logistic regression was used to analyze the risk factors of hyperhomocysteinemia of different genders.Results A total of 720 subjects were included in this study.The median Hcy was 12.78 pmol/L,higher in males(14.82 µ mol/L)than females(9.84 μmol/L),with sta-tistically significant(P＜0.05).The prevalence of hyperhomocysteinemia(HHcy)was 37.64％,with males(48.58％)significantly higher than females(18.39％),and the difference was statistically significant(P＜0.05).The male HHcy group had a higher reatinine(Cr)and lower positive symptom scores(P＜0.05).The total cholesterol(TC)and Cr levels in the female HHcy group were higher than those in the non HHcy group.Multivariate logistic regression analysis showed that creatinine was a risk factor for hyperhomocysteinemia in male and female schizophrenia patients,and positive symptom scores were a protective factor in male schizophrenia patients.Conclusion The level of Hcy and prevalence of HHcy in male patients with schizophrenia are higher than those in female patients,and creatinine levels are closely related to the risk of HHcy.It is recommended to regularly monitor Hcy levels in schizophrenia patients with creatinine abnormalities.
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