The risk factors of hospital infection in elderly schizophrenic patients
Objective To explore the risk factors of hospital infection in elderly patients with schizophrenia.Methods A retrospective analysis was conducted on the clinical data of 198 elderly patients with schizophrenia admit-ted to our hospital from April 2020 to March 2023.They were divided into an uninfected group(n=143)and an infected group(n=55)based on whether hospital infections occurred during hospitalization.Compare two sets of general informa-tion[gender,age,course of disease,number of hospitalizations,length of stay,Positive and Negative Symptom Scale(PANSS),use of two or more antipsychotic drugs,long-term use of antibiotics],as well as nitric oxide(NO),catalase(CAT),total antioxidant capacity(T-AOC)The differences in glutathione peroxidase(GSH-Px)levels were analyzed using multivariate logistic regression to identify the risk factors for hospital acquired infections in elderly patients with schizophrenia.Results The results showed that the non infected group used two or more antipsychotic drugs,the propor-tion of long-term use of antibiotics,PANSS score,and NO level were lower than those of the infected group,while the levels of CAT,GSH-Px,and T-AOC were higher than those of the infected group,with statistical significance(P＜0.05).The results of multivariate logistic regression analysis showed that PANSS score,use of two or more antipsychotic drugs,long-term use of antibiotics,serum CAT,GSH-Px,T-AOC,and NO levels were risk factors for hospital acquired infections in elderly patients with schizophrenia,all with P＜0.05.Conclusion The occurrence of hospital infection in elderly schizophrenia patients is influenced by PANSS score,the use of two or more antipsychotic drugs,long-term use of antibiotics,serum CAT,GSH-Px,T-AOC,and NO levels,and should be closely monitored.
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