目的 探讨外周血中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio，NLR)、单核细胞与淋巴细胞比值(monocyte to lymphocyte ratio，MLR)、血小板与淋巴细胞比值(platelet to lymphocyte ratio，PLR)和全身免疫炎症指数(systemic immune inflammatory index，SII)在抑郁症中的应用价值。方法 选取2023年1月～2023年6月收治的190名抑郁症患者(DP组)及年龄、性别相匹配的100名健康对照者(HC组)，患者组进一步分为两个亚组:伴有精神病性症状的抑郁症患者组(DP1组，87名)、不伴有精神病性症状的抑郁症患者组(DP2组，103人)，分析三组受试者的外周血血小板、中性粒细胞、淋巴细胞、单核细胞计数(monocyte，MON)，比较NLR、MLR、PLR及SII水平的差异，并探讨了抑郁症与炎症指标的关系。结果 患者组MON、MLR、SII水平高于对照组(F=52。561，52。104，18。670，均P＜0。01)，DP 1组与DP 2之间差异虽无统计学意义(P＞0。05)，但伴有精神病性症状的抑郁患者SII有升高的趋势。结论 抑郁症患者MON、MLR和SII升高，不同的抑郁症亚型不影响炎症指标的改变。
Changes in peripheral blood levels of NLR,MLR,PLR,and SII in depressive disorder patients
Objective To explore the role of peripheral blood Neutrophil to Lymphocyte ratio(NLR),Monocyte to Lymphocyte ratio(MLR),Platelet to Lymphocyte ratio(PLR)and Systemic Immune Inflammatory index(SII)in depressive disorder patients.Methods A total of 190 patients with depressive disorder(DP group)and age-and gen-der-matched 100 healthy controls(HC group)admitted from January 2023 to June 2023 were collected.DP group was further divided into two subgroups:depressive disorder with psychotic symptoms(DP 1 group,87 people)and depres-sive disorder without psychotic symptoms(DP 2 group,103 people).Platelet(PLT),Neutrophil(NEU),Lympho-cyte(LYM),and Monocyte(MON)counts were analyzed,the differences in NCR,MLR,PLR,and SII levels were compared between groups,and the relationship between depressive disorder and inflammatory indicators was discussed.Results MON,MLR and SII in the DP group were higher than those in the HC group(F=52.561,52.104,18.670,all P＜0.01).Although there was no significant difference between DP 1 and DP 2(P＞0.05),SII tended to increase in depressed patients with psychotic symptoms.Conclusion In depressive disorder patients,MON,MLR,and SII are elevated,and different subtypes of depressive disorder do not affect changes in inflammatory indicators.
Depressive disorderNeutrophil-to-lymphocyte ratioMonocyte-to-lymphocyte ratioPlatelet-to-lymphocyte ratioSystemic immune-inflammation index
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