目的 探讨老年抑郁症患者应用微生态制剂辅助认知行为干预(Cognitive behavioral therapy，CBT)的临床价值。方法 选取2021年2月～2023年2月在我院门诊收治的160例老年抑郁症患者，随机分为观察组(微生态制剂辅助CBT，80例)和对照组(CBT，80例)。记录两组汉密尔顿抑郁-17(Hamilton depression-17，HAMD-17)量表评分和简易精神状态评价量表(Simple Mental State Assessment Scale，MMSE)评分，检测两组肿瘤坏死因子-α(Tumor necrosis factor-α，TNF-α)、高敏 C 反应蛋白(high-sensitive C-reactive protein，hs-CRP)以及白细胞介素-6(Interleukin-6，IL-6)水平，观察两组不良反应。结果 治疗后两组HAMD-17评分均下降，观察组低于对照组(P＜0。05);治疗后两组患者TNF-α、hs-CRP、IL-6水平显著下降，观察组低于对照组(P＜0。05);治疗后两组MMSE评分均上升，观察组高于对照组(P＜0。05);两组不良反应总发生率比较无显著差异(连续性校正x2=2。025，P=0。155)。结论 微生态制剂辅助CBT能有效减轻老年抑郁症患者的抑郁程度，降低炎症反应，改善认知功能，安全性高。
Effect of cognitive behavioral intervention with microecological agents in elderly patients with depression
Objective To investigate the clinical value of Cognitive behavioral therapy(CBT)assisted by mi-croecological agents in elderly patients with depression.Methods A total of 160 elderly patients with depression ad-mitted to our outpatient hospital from February 2021 to February 2023 were selected and studied,and were randomly divided into observation group(80 cases of microecological-assisted CBT)and control group(80 cases of CBT).Ham-ilton depression-17(HAMD-17)score and Simple Mental State Assessment Scale(MMSE)score were recorded in the two groups.Tumor necrosis factor-α(TNF-α),high-sensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)levels were detected in the two groups,and adverse reactions were observed in the two groups.Results HAMD-17 scores of both groups decreased after treatment,and the observation group was lower than the control group(P＜0.05).After treatment,the levels of TNF-α,hs-CRP and IL-6 in two groups were significantly decreased,and the obser-vation group was lower than the control group(P＜0.05).MMSE scores in both groups increased after treatment,and the observation group was higher than the control group(P＜0.05).There was no significant difference in the total inci-dence of adverse reactions between the two groups(continuity correction x 2=2.025,P=0.155).Conclusion Micro-ecological preparations assisted CBT can effectively reduce the degree of depression in elderly patients with depression,reduce inflammatory response,improve cognitive function,and have high safety.
Senile depressionCognitive behavior therapyMicroecological preparationsCognitive function
NETL
NSTL
万方数据
