改良无抽搐电休克术对难治性强迫症患者的疗效
The effect of modified non-convulsive electroconvulsive therapy in patients with refractory obsessive-compulsive disorder
白树新 1刘德芳 2梁汝沛 2兰波 1刘国勇 1王德斌 1孙文洁 1袁索 1李广玉1
作者信息
- 1. 河北省沧州市人民医院(沧州,061000)
- 2. 华北石油精神康复医院
- 折叠
摘要
目的 探讨改良无抽搐电休克法对难治性强迫症患者的治疗疗效.方法 研究对象为2020年5月～2023年5月来本院就诊的80例难治性强迫症患者,根据随机数字表法将其分为研究组(n=40,改良无抽搐电休克术治疗联合药物治疗)和对照组(n=40,常规药物治疗);两组患者治疗前、治疗后第 2、4、8、12 周采用 Yale-Brown 强迫评定量表(Yale-Brown Obsessive Compulsive Rating Scale,Y-BOCS)、17-汉密顿抑郁量表(17-Hamilton Depression Scale,HAMD-17)、汉密顿焦虑量表(Hamilton Anxiety Scale,HAMA)评估临床治疗效果,以减分率评定临床疗效,采用副反应量表(Treatment Emergent Symptom Scale,TESS)评估两组患者治疗过程中不良反应发生情况.结果 治疗2周末、治疗4周末、治疗8周末及治疗12周末,HAMA、HAMD-17及Y-BOCS评分均低于治疗前(P＜0.05),且研究组均低于对照组(P＜0.05);两组TESS评分无显著差异(P＞0.05).研究组临床治疗总有效率高于对照组(P＜0.05).结论 改良无抽搐电休克法治疗联合常规药物治疗可显著提高难治性强迫症患者治疗效果,且不增加副反应.
Abstract
Objective To investigate the curative effect of modified non-convulsive electroconvulsive therapy on refractory obsessive-compulsive disorder.Methods 80 patients with refractory obsessive-compulsive disorder who visited our hospital from May 2020 to May 2023 were divided into study group(n=40,modified non-convulsive elec-troconvulsive therapy combined with drug therapy)and control group(n=40,conventional drug therapy)according to random number table method.Yale-Brown Obsessive Compulsive Rating Scale(Y-BOCS),17-Hamilton Depression Scale(HAMD-17)and Hamilton Anxiety Scale(HAMA)were used to evaluate the clinical efficacy before treatment and at 2,4,8 and 12 weeks after treatment.The clinical efficacy was evaluated by the reduction rate.The side ef-fects scale(TESS)was used to evaluate the occurrence of adverse reactions during treatment.Results The scores of HAMA,HAMD-17 and Y-BOCS were lower than those before treatment(P＜0.05)at the end of 2nd,4th,8th and 12th week of treatment,and the scores of TESS in study group were lower than those in control group(P＜0.05).The total effective rate of the study group was significantly higher than that of the control group(P＜0.05).Conclusion Modified non-convulsive electroconvulsive therapy combined with routine drug therapy can significantly improve the therapeutic effect of refractory obsessive-compulsive disorder patients without increasing side effects.
关键词
改良无抽搐电休克法治疗/难治性强迫症/焦虑/抑郁/疗效Key words
Modified non-convulsive electroconvulsive therapy/Refractory obsessive-compulsive disorder/Anxiety/Depression/Efficacy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据