艾司西酞普兰对急性心肌梗死患者PCI术后心理应激、睡眠状态及血清PAI-1水平的影响
Effects of escitalopram on psychological stress,sleep status and serum PAI-1 level in patients with acute myocardial infarction after PCI
张义婷 1赵刚 2黄荣兰1
作者信息
- 1. 皖西卫生职业学院附属医院(六安,237008)
- 2. 六安世立医院
- 折叠
摘要
目的 探讨艾司西酞普兰对急性心肌梗死经皮冠状动脉介入治疗(PCI)术后患者心理应激、睡眠状态及血清纤溶酶原激活物抑制因子-1(PAI-1)水平的影响.方法 选取我院2020年2月～2022年8月期间102例急性心肌梗死PCI术后患者为研究对象,依照治疗方案分为心理组和药物组.两组均予急性心肌梗死常规基础治疗,心理组51例给予心理干预,药物组51例在心理组基础上予艾司西酞普兰治疗,比较两组心理应激,睡眠状态,血管内皮功能及PAI-1.结果 药物组治疗8周后广泛性焦虑障碍量表(GAD-7)、健康问卷抑郁自评量表(PHQ-9)、睡眠效率、入睡时间、睡眠质量评分及内皮素-1(ET-1)、PAI-1水平低于心理组(P＜0.05);一氧化氮(NO)水平高于心理组(P＜0.05).结论 艾司西酞普兰可改善急性心肌梗死PCI术后患者血管内皮功能及PAI-1水平,调节心理应激,改善睡眠状态.
Abstract
Objective To investigate the effects of Escitalopram on psychological stress,sleep status and serum plasminogen activator inhibitor-1(PAI-1)level in patients with acute myocardial infarction after percutaneous coronary intervention(PCI).Methods A total of 102 patients with acute myocardial infarction after PCI in our hospital from February 2020 to August 2022 were selected as research objects,and divided into psychological group and drug group according to treatment plan.Both groups received routine basic treatment for acute myocardial infarction,51 cases in the psychological group received psychological intervention,and 51 cases in the drug group received escitalopram on the basis of the psychological group.Psychological stress,sleep status,vascular endothelial function and PAI-1 were compared between the two groups.Results After 8 weeks of treatment,the scores of generalized anxiety Disorder Scale(GAD-7),health questionnaire Self-rating Depression Scale(PHQ-9),sleep efficiency,sleep time,sleep quality,endothelin-1(ET-1)and PAI-1 in drug group were lower than those in psychological group(P＜0.05).The level of nitric oxide(NO)was higher than that of psychological group(P＜0.05).Conclusion Escitalopram can im-prove vascular endothelial function and PAI-1 level,regulate psychological stress and improve sleep status in patients with acute myocardial infarction after PCI.
关键词
艾司西酞普兰/急性心肌梗死/心理应激/睡眠状态Key words
Escitalopram/Acute myocardial infarction/Psychological stress/Sleep state引用本文复制引用
出版年
2024
NETL
NSTL
万方数据