胃食管反流患者负性情绪检出情况及对反流症状的影响
The detection of negative emotion in patients with gastroesophageal reflux and its influence on reflux symptoms
孙振国 1张光伟 1张宁 1苟学蕊 1曹均铭 1邵博文1
作者信息
- 1. 北大医疗鲁中医院消化内二科(淄博,255400)
- 折叠
摘要
目的 探讨胃食管反流患者负性情绪检出情况及对反流症状的影响.方法 本研究纳入北大医疗鲁中医院2020年4月～2023年4月96例胃食管反流病患者,评估患者汉密尔顿抑郁量表 17 项(Hamilton depression scale-17,HAMD-17)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA),设为焦虑抑郁组以及非焦虑抑郁组.比较两组患者一般资料、HAMD评分、HAMD-17评分、胃食管反流病问卷(Gastro-esophageal reflux disease questionnaire,GerdQ),测量食管上、下括约肌静息压(upper/low esophageal sphincter,UESP/LESP).结果 96例胃食管反流病患者检出焦虑情绪6例,抑郁情绪5例,焦虑合并抑郁20例;焦虑抑郁组与非焦虑抑郁组HAMA评分、HAMD-17评分、年龄、病程、合并食管外症状差异具有统计学意义(P＜0.05),两组性别、体质指数差异无统计学意义(P＞0.05);焦虑抑郁组GerdQ评分显著高于非焦虑抑郁组,(P＜0.05),UESP、LESP显著低于非焦虑抑郁组(P＜0.05);焦虑抑郁组HAMD-17评分、HAMA评分与GerdQ评分具有正相关关系,与UESP、LESP具有负相关关系(P＜0.05).结论 胃食管反流患者焦虑抑郁情绪检出率较高,且焦虑抑郁情绪与胃食管反流症状以及食管动力学紊乱相关.
Abstract
Objective To investigate the detection of negative emotion in patients with gastroesophageal reflux and its influence on reflux symptoms.Methods Ninety-six patients with gastroesophageal reflux disease from April 2020 to April 2023 at Luzhong Hospital of Peking University Medical College were selected as the study subjects.The patient's Hamilton Depression Scale-17(HAMD-17)and Anxiety Scale(HAMA)were evaluated.They were set as the anxiety depression group and the non anxiety depression group.The general information of two groups of patients and the Gastro-esophageal reflux disease questionnaire(GerdQ)were compared.The upper/lower esophageal Sphincter resting pressure(UESP/LESP)of two groups of patients were measured.Results Ninety-six patients with gastroesophageal reflux disease were diagnosed with anxiety in 6 cases,depression in 5 cases,and anxiety combined with depression in 20 cases.There was a statistically significant difference in HAMD-17 Scale、HAMD-17 Scale,age,course of disease,and coexisting extraesophageal symptoms between the anxiety and depression group and the non-anxiety and depression group(P＜0.05).There was no statistically significant difference in gender and body mass index between the two groups(P＞0.05).The GerdQ score in the anxiety and depression group was significantly higher than those in the non-anxiety and depression group(P＜0.05),while the UESP and LESP were significantly lower than those of the non-anxiety and depression group(P＜0.05).The HAMD-17 score,HAMA score,and GerdQ score in the anxiety and depression group showed a posi-tive correlation,but a negative correlation with UESP and LESP(P＜0.05).Conclusion The detection rate of anxiety and depression in patients with gastroesophageal reflux disease is relatively high,and anxiety and depression were associ-ated with symptoms of gastroesophageal reflux disease and esophageal dynamic disorders.
关键词
焦虑/抑郁/胃食管反流病/临床症状Key words
Anxiety/Depression/Gastroesophageal reflux disease/Clinical symptoms引用本文复制引用
出版年
2024
NETL
NSTL
万方数据