重症疟疾相关分子机制的研究进展
Research progress on molecular mechanism of severe malaria
王飞 1张青锋2
作者信息
- 1. 200092 上海,同济大学医学院
- 2. 200120 上海,同济大学医学院附属东方医院转化医学研究中心
- 折叠
摘要
由恶性疟原虫感染引起的疟疾导致全球每年100余万病例死亡,其中以脑型疟为代表的重症疟疾是引起疟疾患者死亡的主要原因.目前在临床上对重症疟疾的诊断、病理学分析以及治疗策略方面已比较成熟,但是对重症疟疾发生和发展过程中涉及的分子机制尚未完全清楚.该文对重症疟疾相关的关键分子及其调控机制的研究进展作一综述.
Abstract
Malaria caused by Plasmodium falciparum accounts for approximately one million deaths worldwide,most of whom are killed by severe malaria,particularly cerebral malaria (CM).Currently,it has been well studied on the clinical diagnosis,pathological analysis and therapy strategies,however,little is known of the pathogenesis of severe malaria including the occurrence,development,and involved molecular mechanisms.Here the research advances on the severe malaria-related key molecules,regulatory factors,and pathways were reviewed and discussed.
关键词
凶险型疟疾/var基因家族/恶性疟原虫红细胞表面蛋白-1Key words
Severe malaria/var gene family/Plasmodium falciparum erythrocyte membrane protein 1引用本文复制引用
基金项目
国家自然科学基金(31271388)
国家自然科学基金(81361130411)
出版年
2015
NETL
NSTL
维普
万方数据