MicroRNA在血吸虫病致病机制中的作用
The role of microRNA in pathogenic mechanism of schistosomiasis
蒲广斌 1杨小迪 1孙新1
作者信息
- 1. 233030 蚌埠,蚌埠医学院病原生物学教研室,安徽省感染与免疫重点实验室
- 折叠
摘要
MicroRNA (miRNA)是一类大小约21～25 nt,广泛存在于真核生物和各种病毒体内的非蛋白编码单链小分子RNA,是转录后水平的细胞调控因子.miRNA广泛参与真核生物细胞的生长、发育、代谢、凋亡等生理活动.miRNA也广泛参与血吸虫生长发育及生理代谢过程,在血吸虫感染早期,miRNA在血吸虫和宿主之间起到了非常重要的作用.该文就miRNA在血吸虫病致病机制中的作用作一综述.
Abstract
MicroRNAs (miRNAs) are noncoding RNAs,21～25 nt in length,that widely exist in eukaryotic and a variety of virus.MiRNAs regulate the cell functions in the post-transcription level.MiRNAs widely participate in the cell growth,development,metabolism,apoptosis and other biological process of eukaryotic cells.Moreover,miRNAs are involved in the development of schistosome and its physiological metabolic process.In the early stage of schistosome infection,miRNAs play a vital role between schistosome and the host.In this review,the roles of miRNAs in the pathogenic mechanism of schistosomiasis were summarized.
关键词
血吸虫/血吸虫病/miRNA/肝纤维化Key words
Schistosome/Schistosomiasis/miRNA/Liver fibrosis引用本文复制引用
出版年
2015
NETL
NSTL
维普
万方数据