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MicroRNA在血吸虫病致病机制中的作用

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MicroRNA (miRNA)是一类大小约21~25 nt,广泛存在于真核生物和各种病毒体内的非蛋白编码单链小分子RNA,是转录后水平的细胞调控因子.miRNA广泛参与真核生物细胞的生长、发育、代谢、凋亡等生理活动.miRNA也广泛参与血吸虫生长发育及生理代谢过程,在血吸虫感染早期,miRNA在血吸虫和宿主之间起到了非常重要的作用.该文就miRNA在血吸虫病致病机制中的作用作一综述.
The role of microRNA in pathogenic mechanism of schistosomiasis
MicroRNAs (miRNAs) are noncoding RNAs,21~25 nt in length,that widely exist in eukaryotic and a variety of virus.MiRNAs regulate the cell functions in the post-transcription level.MiRNAs widely participate in the cell growth,development,metabolism,apoptosis and other biological process of eukaryotic cells.Moreover,miRNAs are involved in the development of schistosome and its physiological metabolic process.In the early stage of schistosome infection,miRNAs play a vital role between schistosome and the host.In this review,the roles of miRNAs in the pathogenic mechanism of schistosomiasis were summarized.

SchistosomeSchistosomiasismiRNALiver fibrosis

蒲广斌、杨小迪、孙新

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233030 蚌埠,蚌埠医学院病原生物学教研室,安徽省感染与免疫重点实验室

血吸虫 血吸虫病 miRNA 肝纤维化

2015

国际医学寄生虫病杂志
中华医学会,中国疾病预防控制中心寄生虫病预防控制所

国际医学寄生虫病杂志

CSTPCD
影响因子:0.463
ISSN:1673-4122
年,卷(期):2015.42(2)
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