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蓝氏贾第鞭毛虫潜在致病机制初探

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蓝氏贾第鞭毛虫(简称贾第虫)是一种常见的人兽共患寄生性原虫,由其导致的贾第虫病已被世界卫生组织列为危害人类健康的10种主要寄生虫病之一.近年来,贾第虫病的危害日益受到重视,然而贾第虫导致腹泻的致病机制尚不明确,可能与其细胞骨架蛋白、虫体分泌物、L精氨酸代谢以及表面抗原变异、免疫学改变等多种因素有关,该文对与贾第虫致病机理相关的研究作一综述.
A preliminary exploration of the potential pathogenic mechanism of Giardia lamblia
Giardia lamblia is a common zoonotic parasitic protozoa while giardiasis has been listed as one of the 10 major parasitic diseases endangering human health by World Health Organization.The harmfulness of giardiasis is attracting more and more attentions in recent years,however,the pathogenic mechanism of diarrhea caused by the parasite is still unclear.It may be related to many factors,such as cytoskeletal proteins,excretory/secretory products,L-arginine metabolism,surface antigen and antigenic variation of G.lamblia,and the immunological changes of the host.Researches concerning the pathogenic mechanism of the giardiasis were reviewed in this paper.

Giardia lambliaPathogenic mechanismGiardinsAntigenic variation

余新刚、胡伟、李国清

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510642 广州,华南农业大学兽医学院

蓝氏贾第鞭毛虫 致病机理 贾第素 抗原变异

国家自然科学基金

31272551

2015

国际医学寄生虫病杂志
中华医学会,中国疾病预防控制中心寄生虫病预防控制所

国际医学寄生虫病杂志

CSTPCD
影响因子:0.463
ISSN:1673-4122
年,卷(期):2015.42(2)
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